Fluorine-Containing Chrysin Derivatives

Fluorine-containing Elastomers Introduction

Introduction of fluorine and fluorine-containing functional groups.

Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis. The most challenging transformation remains the formation of the parent C-F bond, primarily as a consequence of the high hydration energy of fluoride, strong metal-fluorine bonds, and highly polarized bonds to fluorine. Most fluori...

A NEW GENERATION OF OXYNITRIDE GLASSES CONTAINING FLUORINE

Oxynitride glasses are found as grain boundary phases in silicon nitride ceramics. They are effectively alumino-silicate glasses in which nitrogen substitutes for oxygen in the glass network, and this causes increases in glass transition and softening temperatures, viscosities (by two to three orders of magnitude), elastic moduli and microhardness. Calcium silicate-based glasses containing fluo...

Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation.

As a part of our project aimed at developing new safe chemotherapeutic and chemoprophylactic agents against tropical diseases, fluorine-containing drugs structurally related to 4-phenoxyphenoxyethyl thiocyanate (1) were designed, synthesized, and evaluated as antiproliferative agents against Trypanosoma cruzi, the parasite responsible of American trypanosomiasis (Chagas' disease), and Toxoplasm...

Synthesis and Comparison of Anti-inflammatory Activity of Chrysin Derivatives

A series of five chrysin derivatives was synthesized and examinated for their antiinflammatory activities. The in vivo anti-inflammatory activity of synthetic compounds was carried out using the model of carrageenan induced mice paw edema. The results showed that methylation of 5,7dihydroxyl groups of chrysin resulted to increase the in vivo bioactivity in comparison with the corresponding chry...